Ackerman Lab

publications

Impact of adjuvants Humoral and cellular immune correlates of protection against COVID-19 in kidney transplant recipients.

Kemlin D, Gemander N, Depickère S, Olislagers V, Georges D, Waegemans A, Pannus P, Lemy A, Goossens ME, Desombere I, Michiels J, Vandevenne M, Heyndrickx L, Ariën KK, Matagne A, Ackerman ME, Le Moine A, Marchant A.
Am J Transplant. 2023 Feb 9:S1600-6135(23)00300-3. doi: 10.1016/j.ajt.2023.02.015.
PMID: 36773936

Impact of adjuvants Safety, tolerability, and immunogenicity of inactivated poliovirus vaccine with or without E.coli double mutant heat-labile toxin (dmLT) adjuvant in healthy adults; a phase 1 randomized study.

Erdem R, De Coster I, Withanage K, Mercer LD, Marchant A, Taton M, Cools N, Lion E, Cassels F, Higgins D, Ivinson K, Locke E, Mahmood K, Wright PF, Gast C, White JA, Ackerman ME, Konopka-Anstadt JL, Mainou BA, Van Damme P.
Vaccine. 2023 Feb 4:S0264-410X(23)00078-6. doi: 10.1016/j.vaccine.2023.01.048.
PMID: 36746739

Impact of adjuvants Younger Children Develop Higher Effector Antibody Responses to SARS-CoV-2 Infection.

Tomasi L, Thiriard A, Heyndrickx L, Georges D, Van den Wijngaert S, Olislagers V, Sharma S, Matagne A, Ackerman ME, Ariën KK, Goetghebuer T, Marchant A.
Open Forum Infect Dis. 2022 Nov 30;9(11):ofac554. doi: 10.1093/ofid/ofac554.
eCollection 2022 Nov.
PMID: 36467295

Impact of adjuvants Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation.

Bharadwaj P, Shrestha S, Pongracz T, Concetta C, Sharma S, Le Moine A, de Haan N, Murakami N, Riella LV, Holovska V, Wuhrer M, Marchant A, Ackerman ME.
Cell Rep Med. 2022 Nov 15;3(11):100818. doi: 10.1016/j.xcrm.2022.100818.
PMID: 36384101

Impact of adjuvants Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.

Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA.
J Exp Med. 2022 Dec 5;219(12):e20220110. doi: 10.1084/jem.20220110.
PMID: 36156707

Impact of adjuvants Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques.

Tolbert WD, Gohain N, Kremer PG, Hederman AP, Nguyen DN, Van V, Sherburn R, Lewis GK, Finzi A, Pollara J, Ackerman ME, Barb AW, Pazgier M.
Front Immunol. 2022 Sep 5;13:960411. doi: 10.3389/fimmu.2022.960411.
PMID: 36131913

Impact of adjuvants Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections.

Backes IM, Leib DA, Ackerman ME.
Front Immunol. 2022 Aug 9;13:959603. doi: 10.3389/fimmu.2022.959603.
PMID: 36016956

Impact of adjuvants Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans.

Xu S, Carpenter MC, Spreng RL, Neidich SD, Sarkar S, Tenney D, Goodman D, Sawant S, Jha S, Dunn B, Juliana McElrath M, Bekker V, Mudrak SV, Flinko R, Lewis GK, Ferrari G, Tomaras GD, Shen X, Ackerman ME.
NPJ Vaccines. 2022 Aug 4;7(1):90. doi: 10.1038/s41541-022-00514-9.
PMID: 35927399

Functional consequences of allotypic polymorphisms Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.

Crowley AR, Richardson SI, Tuyishime M, Jennewein M, Bailey MJ, Lee J, Alter G, Ferrari G, Morris L, Ackerman ME.
Immunogenetics. 2022 Jul 29. doi: 10.1007/s00251-022-01272-7.
PMID: 35904629

Antibody-mediated prevention of vaginal HIV transmission Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice.

Brady JM, Phelps M, MacDonald SW, Lam EC, Nitido A, Parsons D, Boutros CL, Deal CE, Garcia-Beltran WF, Tanno S, Natarajan H, Ackerman ME, Vrbanac VD, Balazs AB.
Sci Transl Med. 2022 Jul 27;14(655):eabn9662. doi: 10.1126/scitranslmed.abn9662. Epub 2022 Jul 27.
PMID: 35895834

lethal SARS-CoV-2 infection Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.

Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M.
Sci Adv. 2022 Jul 15;8(28):eabn4188. doi: 10.1126/sciadv.abn4188. Epub 2022 Jul 13.
PMID: 35857504

HIV-associated alterations HIV-associated alterations of the biophysical features of maternal antibodies correlate with their reduced transfer across the placenta.

Taylor SA, Sharma S, Remmel CAL, Holder B, Jones CE, Marchant A, Ackerman ME.
J Infect Dis. 2022 Jun 6:jiac222. doi: 10.1093/infdis/jiac222.
PMID: 35668706

Boosting Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike.

Crowley AR, Natarajan H, Hederman AP, Bobak CA, Weiner JA, Wieland-Alter W, Lee J, Bloch EM, Tobian AAR, Redd AD, Blankson JN, Wolf D, Goetghebuer T, Marchant A, Connor RI, Wright PF, Ackerman ME.
Elife. 2022 Mar 15;11:e75228. doi: 10.7554/eLife.75228.
PMID: 35289271.

purified Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges.

Lakhashe SK, Amacker M, Hariraju D, Vyas HK, Morrison KS, Weiner JA, Ackerman ME, Roy V, Alter G, Ferrari G, Montefiori DC, Tomaras GD, Sawant S, Yates NL, Gast C, Fleury S, Ruprecht RM.
Front Immunol. 2022 Feb 22;13:788619. doi: 10.3389/fimmu.2022.788619.
PMID: 35273592

Longitudinal Longitudinal Systemic and Mucosal Immune Responses to SARS-CoV-2 Infection.

Wright PF, Prevost-Reilly AC, Natarajan H, Brickley EB, Connor RI, Wieland-Alter WF, Miele AS, Weiner JA, Nerenz RD, Ackerman ME.
J Infect Dis. 2022 Feb 21:jiac065. doi: 10.1093/infdis/jiac065.
PMID: 35188974

neutralization Antibody attributes that predict the neutralization and effector function of polyclonal responses to SARS-CoV-2.

Natarajan H, Xu S, Crowley AR, Butler SE, Weiner JA, Bloch EM, Littlefield K, Benner SE, Shrestha R, Ajayi O, Wieland-Alter W, Sullivan D, Shoham S, Quinn TC, Casadevall A, Pekosz A, Redd AD, Tobian AAR, Connor RI, Wright PF, Ackerman ME.
BMC Immunol. 2022 Feb 16;23(1):7. doi: 10.1186/s12865-022-00480-w.
PMID: 35172720

Broad Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.

Kaku CI, Champney ER, Normark J, Garcia M, Johnson CE, Ahlm C, Christ W, Sakharkar M, Ackerman ME, Klingström J, Forsell MNE, Walker LM.
Science. 2022 Feb 10:eabn2688. doi: 10.1126/science.abn2688.
PMID: 35143256

Phagocytosis Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis.

Spencer DA, Goldberg BS, Pandey S, Ordonez T, Dufloo J, Barnette P, Sutton WF, Henderson H, Agnor R, Gao L, Bruel T, Schwartz O, Haigwood NL, Ackerman ME, Hessell AJ.
Nat Commun. 2022 Feb 3;13(1):662. doi: 10.1038/s41467-022-28250-7.
PMID: 35115533

poor_antibody Poor antibody response to BioNTech/Pfizer COVID-19 vaccination in SARS-CoV-2 naïve residents of nursing homes.

Pannus P, Neven KY, De Craeye S, Heyndrickx L, Vande Kerckhove S, Georges D, Michiels J, Francotte A, Van Den Bulcke M, Zrein M, Van Gucht S, Schmickler MN, Verbrugghe M, Matagne A, Thomas I, Dierick K, Weiner JA, Ackerman ME, Goriely S, Goossens ME,Ariën KK, Desombere I, Marchant A.
Clin Infect Dis. 2021 Dec 3:ciab998. doi: 10.1093/cid/ciab998.
PMID: 34864935

delayed Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies.

Das J, Fallon JK, Yu TC, Michell A, Suscovich TJ, Linde C, Natarajan H, Weiner J, Coccia M, Gregory S, Ackerman ME, Bergmann-Leitner E, Fontana L, Dutta S, Lauffenburger DS, Jongert E, Wille-Reece U, Alter G.
Med 2, 1269–1286, 2021 Nov 12. doi: 10.1016/j.medj.2021.10.003

diverse Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features.

Cheng HD, Dowell KG, Bailey-Kellogg C, Goods BA, Love JC, Ferrari G, Alter G, Gach J, Forthal DN, Lewis GK, Greene K, Gao H, Montefiori DC, Ackerman ME.
Retrovirology. 2021 Oct 30;18(1):35. doi: 10.1186/s12977-021-00579-9.
PMID: 34717659

biophysical Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors.

Crowley AR, Osei-Owusu NY, Dekkers G, Gao W, Wuhrer M, Magnani DM, Reimann KA, Pincus SH, Vidarsson G, Ackerman ME.
Front Immunol. 2021 Oct 12;12:754710. doi: 10.3389/fimmu.2021.754710.
PMID: 34712242

crossroads The Crossroads of Glycoscience, Infection, and Immunology.

McKitrick TR, Ackerman ME, Anthony RM, Bennett CS, Demetriou M, Hudalla GA, Ribbeck K, Ruhl S, Woo CM, Yang L, Zost SJ, Schnaar RL, Doering TL.
Front Microbiol. 2021 Sep 27;12:731008. doi: 10.3389/fmicb.2021.731008.
PMID: 34646251

Glycosylation_new Glycosylation of Antigen-Specific Antibodies: Perspectives on Immunoglobulin G Glycosylation in Vaccination and Immunotherapy.

Bharadwaj P, Ackerman ME.
Exp Suppl. 2021;112:565-587. doi: 10.1007/978-3-030-76912-3_18.
PMID: 34687023

Broadly_Neutralizing Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity.

Goldberg BS, Kaku CI, Dufloo J, Bruel T, Schwartz O, Spencer DA, Hessell AJ. Ackerman ME.
mBio. 2021 Oct 12:e0174321. doi: 10.1128/mBio.01743-21.
PMID: 34634936

incorporating Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions.

Sherburn R, Tolbert WD, Gottumukkala S, Hederman AP, Beaudoin-Bussières G, Stanfield-Oakley S, Tuyishime M, Ferrari G, Finzi A, Ackerman ME, Pazgier M.
Vaccines (Basel). 2021 Aug 31;9(9):975. doi: 10.3390/vaccines9090975.
PMID: 34579212

Mucosal immunity to poliovirus. Mucosal immunity to poliovirus.

Connor RI, Brickley EB, Wieland-Alter WF, Ackerman ME, Weiner JA, Modlin JF, Bandyopadhyay AS, Wright PF.
Mucosal Immunol. 2021 Jul 8. doi: 10.1038/s41385-021-00428-0.
PMID: 34239028

Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques. Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.

Pollara J, Tay MZ, Edwards RW, Goodman D, Crowley AR, Edwards RJ, Easterhoff D, Conley HE, Hoxie T, Gurley T, Jones C, Machiele E, Tuyishime M, Donahue E, Jha S, Spreng RL, Hope TJ, Wiehe K, He MM, Moody MA, Saunders KO, Ackerman ME, Ferrari G, Tomaras GD.
Front Immunol. 2021 May 20;12:678511. doi: 10.3389/fimmu.2021.678511.
PMID: 34093580

Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells. Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells.

Rossignol ED, Dugast AS, Compere H, Cottrell CA, Copps J, Lin S, Cizmeci D, Seaman MS, Ackerman ME, Ward AB, Alter G, Julg B.
Cell Rep. 2021 May 25;35(8):109167. doi: 10.1016/j.celrep.2021.109167.
PMID: 34038720

Immunoprofiling Correlates of Protection Against SHIV Infection in Adjuvanted HIV-1 Pox-Protein Vaccinated Rhesus Macaques. Immunoprofiling Correlates of Protection Against SHIV Infection in Adjuvanted HIV-1 Pox-Protein Vaccinated Rhesus Macaques.

Lu P, Guerin DJ, Lin S, Chaudhury S, Ackerman ME, Bolton DL, Wallqvist A.
Front Immunol. 2021 May 11;12:625030. doi: 10.3389/fimmu.2021.625030. eCollection 2021.
PMID: 34046030

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30. Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.

Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME.
Cancer Immunol Immunother. 2021 May 27. doi: 10.1007/s00262-021-02971-y. Online ahead of print.
PMID: 34046711

Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma. Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma.

Natarajan H, Crowley AR, Butler SE, Xu S, Weiner JA, Bloch EM, Littlefield K, Wieland-Alter W, Connor RI, Wright PF, Benner SE, Bonny TS, Laeyendecker O, Sullivan D, Shoham S, Quinn TC, Larman HB, Casadevall A, Pekosz A, Redd AD, Tobian AAR,Ackerman ME.
mBio. 2021 Apr 20;12(2):e00765-21. doi: 10.1128/mBio.00765-21.
PMID:33879585

dd Diverse contributions of avidity to the broad neutralization of Dengue virus by antibodies targeting the E dimer epitope.

Remmel JL,Frei JC, Butler SE,Lai JR, Ackerman ME.
Virology. 2021 Mar 30;559:57-64. doi: 10.1016/j.virol.2021.03.013.
PMID:33819753

cc Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.

Morgenlander WR, Henson SN, Monaco DR, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Balagopal A, Sullivan D, Shoham S, Quinn TC, Eshleman S, Casadevall A, Redd AD, Laeyendecker O,Ackerman ME. Pekosz A, Elledge SJ, Robinson ML, Tobian AA, Larman HB.
J Clin Invest. 2021 Feb 11:146927. doi: 10.1172/JCI146927.
PMID:33571169

bb Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals.

Butler SE, Crowley AR, Natarajan H, Xu S, Weiner JA,Bobak CA, MattoxDE, Lee J, Wieland-Alter W, Connor RI, Wright PF,Ackerman ME.
Front Immunol. 2021 Jan 28;11:618685. doi: 10.3389/fimmu.2020.618685.
PMID:33584712

ww Coming together at the hinges: Therapeutic prospects of IgG3.

Chu TH, Patz EF Jr,Ackerman ME.
MAbs. 2021 Jan-Dec;13(1):1882028. doi: 10.1080/19420862.2021.1882028.
PMID:33602056

Random_walksRationalizing Random Walks: Replicating Protective Antibody Trajectories.

Remmel JL, Ackerman ME.
Trends Immunol. 2021 Jan 26:S1471-4906(21)00001-6. doi: 10.1016/j.it.2021.01.001.
PMID: 33514459

Polyfunctional_tier_2Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor.

Spencer DA, Malherbe DC, Vázquez Bernat N, Ádori M, Goldberg B, Dambrauskas N, Henderson H, Pandey S, Cheever T, Barnette P, Sutton WF, Ackerman ME, Kobie JJ, Sather DN, Karlsson Hedestam GB, Haigwood NL, Hessell AJ.J Immunol. 2021 Jan 20:ji2001082. doi: 10.4049/jimmunol.2001082.
PMID: 33472907

intestinal_antibodyIntestinal antibody responses to two novel live attenuated type 2 oral poliovirus vaccines in healthy adults in Belgium.

Brickley EB, Connor RI, Wieland-Alter W, Weiner JA, Ackerman ME, Arita M, Gast C, De Coster I, Van Damme P, Bandyopadhyay AS, Wright PF.J Infect Dis. 2020 Dec 24:jiaa783. doi: 10.1093/infdis/jiaa783.
PMID: 33367918

RV144_HIV-1RV144 HIV-1 vaccination impacts post-infection antibody responses.

Mdluli T, Jian N, Slike B, Paquin-Proulx D, Donofrio G, Alrubayyi A, Gift S, Grand Bryson M, Lee A, Dussupt V, Mendez-Riveria L, Sanders-Buell E, Chenine AL, Tran U, L Brown E, Edlefsen PT, O'Connell R, Gilbert P, Nitayaphan S, Pitisuttihum P, Rerks-Ngar Robb ML, Gramzinski R, Alter G, Tovanabutra S, Georgiev IS, Ackerman ME, Polonis VR, V S, Michael NL, Kim JH, Eller MA, Krebs SJ, Rolland M.
PLoS Pathog. 2020 Dec 8;16(12):e1009101. doi: 10.1371/journal.ppat.1009101.
PMID: 33290394

33048992Mining for humoral correlates of HIV control and latent reservoir size.

Das J, Devadhasan A, Linde C, Broge T, Sassic J, Mangano M, O'Keefe S, Suscovich T, Streeck H, Irrinki A, Pohlmeyer C, Min-Oo G, Lin S, Weiner JA, Cihlar T, Ackerman ME, Julg B, Deeks S, Lauffenburger DA, Alter G.
PLoS Pathog. 2020 Oct 13;16(10):e1008868. doi: 10.1371/journal.ppat.1008868.
PMID: 33048992

33031099IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees.

Fischinger S, Dolatshahi S, Jennewein MF, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Michael NL, Vasan S, Ackerman ME, Streeck H, Alter G. JCI Insight. 2020 Oct 8:140925. doi: 10.1172/jci.insight.140925.
PMID: 33031099

32881968Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

Om K, Paquin-Proulx D, Montero M, Peachman K, Shen X, Wieczorek L, Beck Z, Weiner JA, Kim D, Li Y, Mdluli T, Shubin Z, Bryant C, Sharma V, Tokarev A, Dawson P, White Y, Appelbe O, Klatt NR, Tovanabutra S, Estes JD, Matyas GR, Ferrari G, Alving CR, Tomaras GD, Ackerman ME, Michael NL, Robb ML, Polonis V, Rolland M, Eller MA, Rao M, Bolton DL. PLoS Pathog. 2020 Sep 3;16(9):e1008764. doi: 10.1371/journal.ppat.1008764.
PMID: 32881968

32849622Tracking the Trajectory of Functional Humoral Immune Responses Following Acute HIV Infection.

Jennewein MF, Mabuka J, Papia CL, Boudreau CM, Dong KL, Ackerman ME, Ndung'u T, Alter G. Front Immunol. 2020 Aug 7;11:1744. doi: 10.3389/fimmu.2020.01744. eCollection 2020.
PMID: 32849622

32718991Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination.

Suscovich TJ, Fallon JK, Das J, Demas AR, Crain J, Linde CH, Michell A, Natarajan H, Arevalo C, Broge T, Linnekin T, Kulkarni V, Lu R, Slein MD, Luedemann C, Marquette M, March S, Weiner J, Gregory S, Coccia M, Flores-Garcia Y, Zavala F, Ackerman ME, Bergmann-Leitner E, Hendriks J, Sadoff J, Dutta S, Bhatia SN, Lauffenburger DA, Jongert E, Wille-Reece U, Alter G.
Sci Transl Med. 2020 Jul 22;12(553):eabb4757. doi: 10.1126/scitranslmed.abb4757.
PMID: 32718991

32690707Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody.

Asokan M, Dias J, Liu C, Maximova A, Ernste K, Pegu A, McKee K, Shi W, Chen X, Almasri C, Promsote W, Ambrozak DR, Gama L, Hu J, Douek DC, Todd JP, Lifson JD, Fourati S, Sekaly RP, Crowley AR, Ackerman ME, Ko SH, Kilam D, Boritz EA, Liao LE, Best K, Perelson AS, Mascola JR, Koup RA.Proc Natl Acad Sci U S A. 2020 Jul 20:202008236. doi: 10.1073/pnas.2008236117.
PMID: 32690707

32675573Recent insights into Fc-mediated effector responses to HIV-1.

Carpenter MC, Ackerman ME.
Curr Opin HIV AIDS. 2020 Jul 15. doi: 10.1097/COH.0000000000000638.
PMID: 32675573

32554928Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response.

Fischinger S, Shin S, Boudreau CM, Ackerman M, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kim JH, Robb ML, Michael NL, O'Connell RJ, Vasan S, Streeck H, Alter G.
JCI Insight. 2020 Jun 18;5(12):135057. doi: 10.1172/jci.insight.135057.
PMID: 32554928

32574486Combinatorial resurfacing of Dengue envelope protein domain III antigens selectively ablates epitopes associated with serotype-specific or infection-enhancing antibody responses.

Remmel JL, Beauchemin KS, Mishra AK, Frei JC, Lai JR, Bailey-Kellogg C, Ackerman ME.
ACS Comb Sci. 2020 Jun 23. doi: 10.1021/acscombsci.0c00073. Online ahead of print.
PMID: 32574486

32402293Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.

Felber BK, Lu Z, Hu X, Valentin A, Rosati M, Remmel CAL, Weiner JA, Carpenter MC, Faircloth K, Stanfield-Oakley S, Williams WB, Shen X, Tomaras GD, LaBranche CC, Montefiori D, Trinh HV, Rao M, Alam MS, Vandergrift NA, Saunders KO, Wang Y, Rountree W, Das J, Alter G, Reed SG, Aye PP, Schiro F, Pahar B, Dufour JP, Veazey RS, Marx PA, Venzon DJ, Shaw GM, Ferrari G, Ackerman ME, Haynes BF, Pavlakis GN.
Cell Rep. 2020 May 12;31(6):107624. doi: 10.1016/j.celrep.2020.107624.
PMID: 32402293

32192810Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity.

Lai JI, Eszterhas SK, Brooks SA, Guo C, Zolla-Pazner S, Seaman MS, Bailey-Kellogg C, Griswold KE, Ackerman ME.
Vaccine. 2020 Mar 16. pii: S0264-410X(20)30354-6. doi: 10.1016/j.vaccine.2020.03.010.
PMID: 32192810

32142167Antibody-mediated complement activation in pathology and protection.

Goldberg BS, Ackerman ME.
Immunol Cell Biol. 2020 Mar 6. doi: 10.1111/imcb.12324.
PMID: 32142167

32111530Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health.

Pasetti MF, Ackerman ME, Hoen AG, Alter G, Tsang JS, Marchant A.
Vaccine. 2020 Feb 25. pii: S0264-410X(20)30082-7. doi: 10.1016/j.vaccine.2020.01.056.
PMID: 32111530

32035517Vaccine boosts: balancing response magnitude and character.

Crowley AR, Ackerman ME.
Lancet HIV. 2020 Feb 6. pii: S2352-3018(19)30435-7. doi: 10.1016/S2352-3018(19)30435-7.
PMID: 32035517

32070674Implementation of a three-tiered approach to identify and characterize anti-drug antibodies raised against HIV-specific broadly neutralizing antibodies.

Bharadwaj P, Riekofski C, Lin S, Seaman MS, Garber DA, Montefiori D, Sarzotti-Kelsoe M, Ackerman ME, Weiner JA.
J Immunol Methods. 2020 Feb 15:112764. doi: 10.1016/j.jim.2020.112764.
PMID: 32070674

32092122Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies.

Chu TH, Crowley AR, Backes I, Chang C, Tay M, Broge T, Tuyishime M, Ferrari G, Seaman MS, Richardson SI, Tomaras GD, Alter G, Leib D, Ackerman ME.
PLoS Pathog. 2020 Feb 24;16(2):e1008083. doi: 10.1371/journal.ppat.1008083.
PMID: 32092122

31917969 Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs.

Seaman MS, Bilska M, Ghantous F, Eaton A, LaBranche CC, Greene K, Gao H, Weiner JA, Ackerman ME, Garber DA, Rosenberg YJ, Sarzotti-Kelsoe M, Montefiori DC.
J Immunol Methods. 2020 Jan 6:112736. doi: 10.1016/j.jim.2020.112736.
PMID: 31917969

31841557 IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

Richardson SI, Lambson BE, Crowley AR, Bashirova A, Scheepers C, Garrett N, Abdool Karim S, Mkhize NN, Carrington M, Ackerman ME, Moore PL, Morris L.
PLoS Pathog. 2019 Dec 16;15(12):e1008064. doi: 10.1371/journal.ppat.1008064
PMID: 31841557

31669096IgG Fc glycosylation as an axis of humoral immunity in childhood.

Cheng HD, Tirosh I, de Haan N, Stöckmann H, Adamczyk B, McManus CA, O'Flaherty R, Greville G, Saldova R, Bonilla FA, Notarangelo LD, Driessen GJ, Holm IA, Rudd PM, Wuhrer M, Ackerman ME, Nigrovic PA.
J Allergy Clin Immunol. 2019 Oct 24. pii: S0091-6749(19)31364-8. doi: 10.1016/j.jaci.2019.10.012.
PMID: 31669096

31581292Longitudinal antibody responses in people who inject drugs infected with similar HIV strains.

Redd AD, Doria-Rose NA, Weiner JA, Nason M, Seivers M, Schmidt SD, Laeyendecker O, Martens C, Bruno D, Keele BF, Raju N, Georgiev IS, Lamers SL, Astemborski J, Kirk GD, Mascola JR, Ackerman ME, Mehta SH, Quinn TC.
J Infect Dis. 2019 Oct 4. pii: jiz503. doi: 10.1093/infdis/jiz503. [Epub ahead of print]
PMID: 31581292

31543993Intestinal antibody responses to a live oral poliovirus vaccine challenge among adults previously immunized with inactivated polio vaccine in Sweden.

Brickley EB, Connor RI, Wieland-Alter WF, Collett MS, Hartford M, Van Der Avoort H, Boesch AW, Weiner JA, Ackerman ME, McKinlay MA, Arita M, Bandyopadhyay AS, Modlin JF, Wright PF.
BMJ Glob Health. 2019 Aug 28;4(4):e001613. doi: 10.1136/bmjgh-2019-001613. eCollection 2019.
PMID: 31543993

31393868Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.

Cohen YZ, Butler AL, Millard K, Witmer-Pack M, Levin R, Unson-O'Brien C, Patel R, Shimeliovich I, Lorenzi JCC, Horowitz J, Walsh SR, Lin S, Weiner JA, Tse A, Sato A, Bennett C, Mayer B, Seaton KE, Yates NL, Baden LR, deCamp AC, Ackerman ME, Seaman MS, Tomaras GD, Nussenzweig MC, Caskey M.
PLoS One. 2019 Aug 8;14(8):e0219142. doi: 10.1371/journal.pone.0219142. eCollection 2019.
PMID: 31393868

31204101Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.

Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR 3rd, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR.
Cell. 2019 Jun 11. pii: S0092-8674(19)30617-8. doi: 10.1016/j.cell.2019.05.046.
PMID:31204101

31134085Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1

Lewis GK, Ackerman ME, Scarlatti G, Moog C, Robert-Guroff M, Kent SJ, Overbaugh J, Reeves RK, Ferrari G, Thyagarajan B.
Front Immunol. 2019 May 10;10:1025. doi: 10.3389/fimmu.2019.01025. eCollection 2019. Review.
PMID:31134085

31048360Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection.

Pittala S, Bagley K, Schwartz JA, Brown EP, Weiner JA, Prado IJ, Zhang W, Xu R, Ota-Setlik A, Pal R, Shen X, Beck C, Ferrari G, Lewis GK, LaBranche CC, Montefiori DC, Tomaras GD, Alter G, Roederer M, Fouts TR, Ackerman ME, Bailey-Kellogg C.
Mol Syst Biol. 2019 May 2;15(5):e8747. doi: 10.15252/msb.20188747.
PMID:31048360

31033729Systems serology for decoding infection and vaccine-induced antibody responses to HIV-1.

Pittala S, Morrison KS, Ackerman ME.
Curr Opin HIV AIDS. 2019 Apr 24. doi: 10.1097/COH.0000000000000558. [Epub ahead of print]
PMID:31033729

30971454Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.

Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA.
Sci Transl Med. 2019 Apr 10;11(487). pii: eaau6039. doi: 10.1126/scitranslmed.aau6039.
PMID:30971454

31024542Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function.

Crowley AR, Ackerman ME.
Front Immunol. 2019 Apr 8;10:697. doi: 10.3389/fimmu.2019.00697. eCollection 2019. Review.
PMID:31024542

30376086Intestinal Immunity to Poliovirus Following Sequential Trivalent Inactivated Polio Vaccine/Bivalent Oral Polio Vaccine and Trivalent Inactivated Polio Vaccine-only Immunization Schedules: Analysis of an Open-label, Randomized, Controlled Trial in Chilean Infants.

Brickley EB, Wieland-Alter W, Connor RI, Ackerman ME, Boesch AW, Arita M, Weldon WC, O'Ryan MG, Bandyopadhyay AS, Wright PF.
Clin Infect Dis. 2018 Oct 30;67(suppl_1):S42-S50. doi: 10.1093/cid/ciy603.
PMID:30376086

30232424Evidence that CD32a does not mark the HIV-1 latent reservoir.

Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB.
Nature. 2018 Sep;561(7723):E20-E28. doi: 10.1038/s41586-018-0495-2. Epub 2018 Sep 19. No abstract available. Erratum in: Nature. 2018 Oct 12.
PMID:30232424

30177821Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.

Ackerman ME, Das J, Pittala S, Broge T, Linde C, Suscovich TJ, Brown EP, Bradley T, Natarajan H, Lin S, Sassic JK, O'Keefe S, Mehta N, Goodman D, Sips M, Weiner JA, Tomaras GD, Haynes BF, Lauffenburger DA, Bailey-Kellogg C, Roederer M, Alter G.
Nat Med. 2018 Sep 3. doi: 10.1038/s41591-018-0161-0. [Epub ahead of print]
PMID:30177821

30161231Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?

Martinez DR, Fouda GG, Peng X, Ackerman ME, Permar SR.
PLoS Pathog. 2018 Aug 30;14(8):e1007161. doi: 10.1371/journal.ppat.1007161. eCollection 2018 Aug.
PMID:30161231

30120121 Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.

Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter G.
Sci Immunol. 2018 Aug 17;3(26). pii: eaat7796. doi: 10.1126/sciimmunol.aat7796.
PMID:30120121

30021899Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques.

Miller-Novak LK, Das J, Musich TA, Demberg T, Weiner JA, Venzon DJ, Mohanram V, Vargas-Inchaustegui DA, Tuero I, Ackerman ME, Alter G, Robert-Guroff M.
J Virol. 2018 Jul 18. pii: JVI.00721-18. doi: 10.1128/JVI.00721-18.
PMID:30021899

29897567Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen.

Lai JI, Verma D, Bailey-Kellogg C, Ackerman ME.
Protein Eng Des Sel. 2018 Jun 12. doi: 10.1093/protein/gzy010. [Epub ahead of print]
PMID:29897567

29630668HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.

Richardson SI, Chung AW, Natarajan H, Mabvakure B, Mkhize NN, Garrett N, Abdool Karim S, Moore PL, Ackerman ME, Alter G, Morris L.
PLoS Pathog. 2018 Apr 9;14(4):e1006987. doi: 10.1371/journal.ppat.1006987. [Epub ahead of print]
PMID:29630668

29453518Chimeric antigen receptors with human scFvs preferentially induce T cell anti-tumor activity against tumors with high B7H6 expression..

Gacerez AT, Hua CK, Ackerman ME, Sentman CL.
Cancer Immunol Immunother. 2018 Feb 16. doi: 10.1007/s00262-018-2124-1. [Epub ahead of print]
PMID:29453518

29581149High-resolution definition of humoral immune response correlates of effective immunity against HIV.

Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman ME.
Mol Syst Biol. 2018 Mar 26;14(3):e7881. doi: 10.15252/msb.20177881.
PMID:29581149

29515029Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site.

Cheng HD, Grimm SK, Gilman MS, Gwom LC, Sok D, Sundling C, Donofrio G, Hedestam GBK, Bonsignori M, Haynes BF, Lahey TP, Maro I, von Reyn CF, Gorny MK, Zolla-Pazner S, Walker BD, Alter G, Burton DR, Robb ML, Krebs SJ, Seaman MS, Bailey-Kellogg C, Ackerman ME.
JCI Insight. 2018 Mar 8;3(5). pii: 97018. doi: 10.1172/jci.insight.97018. [Epub ahead of print]
PMID:29515029

29395167Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV.

Brown EP, Weiner JA, Lin S, Natarajan H, Normandin E, Barouch DH, Alter G, Sarzotti-Kelsoe M, Ackerman ME.
J Immunol Methods. 2018 Jan 29. pii: S0022-1759(17)30302-2. doi: 10.1016/j.jim.2018.01.013. [Epub ahead of print]
PMID:29395167

29315477 Enrichment of high affinity subclasses and glycoforms from serum-derived IgG using FcγRs as affinity ligands.

Boesch AW, Kappel JH, Mahan AE, Chu TH, Crowley AR, Osei-Owusu NY, Alter G, Ackerman ME.
Biotechnol Bioeng. 2018 Jan 8. doi: 10.1002/bit.26545. [Epub ahead of print]
PMID:29315477

29304199Intestinal Immune Responses to Type 2 Oral Polio Vaccine (OPV) Challenge in Infants Previously Immunized With Bivalent OPV and Either High-Dose or Standard Inactivated Polio Vaccine.

Brickley EB, Strauch CB, Wieland-Alter WF, Connor RI, Lin S, Weiner JA, Ackerman ME, Arita M, Oberste MS, Weldon WC, Sáez-Llorens X, Bandyopadhyay AS, Wright PF.
J Infect Dis. 2018 Jan 17;217(3):371-380. doi: 10.1093/infdis/jix556.
PMID:29304199

29309656Mucosal Immunity: The Forgotten Arm of the Immune System: Synopsis of the Pediatric Infectious Disease Society's 2017 Stanley A. Plotkin Lecture in Vaccinology.

Wright PF, Ackerman ME, Brickley EB.
J Pediatric Infect Dis Soc. 2017 Dec 22. doi: 10.1093/jpids/pix102. [Epub ahead of print]
PMID:29309656

 

29234320Increasing the Clinical Potential and Applications of Anti-HIV Antibodies.

Hua CK, Ackerman ME.
Front Immunol. 2017 Nov 28;8:1655. doi: 10.3389/fimmu.2017.01655. eCollection 2017. Review.
PMID:29234320

 

 

29199956Computationally-driven identification of antibody epitopes.

Hua CK, Gacerez AT, Sentman CL, Ackerman ME, Choi Y, Bailey-Kellogg C.
Elife. 2017 Dec 4;6. pii: e29023. doi: 10.7554/eLife.29023.
PMID:29199956

 

 

2017011411Innate transcriptional effects by adjuvants on the magnitude, quality, and durability2017 of HIV envelope responses in NHP

Francica JR, Zak DE, Linde C, Siena E, Johnson C, Juraski M, Yates NL, Gunn B, De Gregorio E, Flynn BJ, Valiante NM, Malyala P, Barnett SW, Sarkar P, Singh M, Jain S, Ackerman M, Alam M, Ferrari G, Tomaras GD, O'Hagan DT, Aderem A, Alter G, Seder RA.
Blood Advances. 2017 1:2329-2342; doi: https://doi.org/10.1182/bloodadvances.2017011411

 

29083319HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells.

Veenhuis RT, Freeman ZT, Korleski J, Cohen LK, Massaccesi G, Tomasi A, Boesch AW, Ackerman ME, Margolick JB, Blankson JN, Chattergoon MA, Cox AL.
J Clin Invest. 2017 Oct 30. pii: 95375. doi: 10.1172/JCI95375. [Epub ahead of print]
PMID:29083319

 

29040754Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6.

Hua CK, Gacerez AT, Sentman CL, Ackerman ME.
Protein Eng Des Sel. 2017 Oct 11:1-9. doi: 10.1093/protein/gzx051. [Epub ahead of print]
PMID:29040754

Related citations

 

28973482High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis.

Cheng HD, Stöckmann H, Adamczyk B, McManus CA, Ercan A, Holm IA, Rudd PM, Ackerman ME*, Nigrovic PA*.
Glycobiology. 2017 Sep 14. doi: 10.1093/glycob/cwx082. [Epub ahead of print]
PMID:28973482

Related citations

 

28933630Going Native: direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins.

Fang Y, Chu TH, Ackerman ME, Griswold KE.
MAbs. 2017 Sep 21:0. doi: 10.1080/19420862.2017.1381812. [Epub ahead of print]
PMID:28933630

Related citations

 

28593989Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.

Bradley T, Pollara J, Santra S, Vandergrift N, Pittala S, Bailey-Kellogg C, Shen X, Parks R, Goodman D, Eaton A, Balachandran H, Mach LV, Saunders KO, Weiner JA, Scearce R, Sutherland LL, Phogat S, Tartaglia J, Reed SG, Hu SL, Theis JF, Pinter A, Montefiori DC, Kepler TB, Peachman KK, Rao M, Michael NL, Suscovich TJ, Alter G, Ackerman ME, Moody MA, Liao HX, Tomaras G, Ferrari G, Korber BT, Haynes BF.
Nat Commun. 2017 Jun 8;8:15711. doi: 10.1038/ncomms15711.
PMID:28593989

Related citations

28235027Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, Vasan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Liao HX, Ferrari G, Seaman MS, Montefiori DC, Tomaras GD, Harrison SC, Haynes BF.
PLoS Pathog. 2017 Feb 24;13(2):e1006182. doi: 10.1371/journal.ppat.1006182. [Epub ahead of print]
PMID:28235027

Related citations

28133810Systems serology for evaluation of HIV vaccine trials.

Ackerman ME, Barouch DH, Alter G.
Immunol Rev. 2017 Jan;275(1):262-270. doi: 10.1111/imr.12503. Review.
PMID:28133810

Related citations

 

28133810Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles.

Brown EP, Dowell KG, Boesch AW, Normandin E, Mahan AE, Chu T, Barouch DH, Bailey-Kellogg C, Alter G, Ackerman ME.
J Immunol Methods. 2017 Feb 2. pii: S0022-1759(16)30386-6. doi: 10.1016/j.jim.2017.01.010.
PMID:28163018

Related citations

graphicIgG Fc variant cross-reactivity between human and rhesus macaque FcγRs.

Boesch AW, Miles AR, Chan YN, Osei-Owusu NY, Ackerman ME.
MAbs. 2017 Jan 5:0. doi: 10.1080/19420862.2016.1274845.
PMID:28055295

Related citations

 

graphicBiophysical and Functional Characterization of Rhesus Macaque IgG Subclasses.

Boesch AW, Osei-Owusu NY, Crowley AR, Chu TH, Chan YN, Weiner JA, Bharadwaj P, Hards R, Adamo ME, Gerber SA, Cocklin SL, Schmitz JE, Miles AR, Eckman JW, Belli AJ, Reimann KA, Ackerman ME.
Front Immunol. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589.
PMID:28018355

Related citations

graphicDiversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects.

Huang Y, Ferrari G, Alter G, Forthal DN, Kappes JC, Lewis GK, Love JC, Borate B, Harris L, Greene K, Gao H, Phan TB, Landucci G, Goods BA, Dowell KG, Cheng HD, Bailey-Kellogg C, Montefiori DC, Ackerman ME.
J Immunol. 2016 Dec 15;197(12):4603-4612.
PMID:27913647

 

graphicVaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants.

Wright PF, Connor RI, Wieland-Alter WF, Hoen AG, Boesch AW, Ackerman ME, Oberste MS, Gast C, Brickley EB, Asturias EJ, Rüttimann R, Bandyopadhyay AS.
Lancet Infect Dis. 2016 Sep 13. pii: S1473-3099(16)30169-4. doi: 10.1016/S1473-3099(16)30169-4.
PMID:27638357

Related citations

graphicDendritic cells from the human female reproductive tract rapidly capture and respond to HIV.

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C, Wira CR.
Mucosal Immunol. 2016 Aug 31. doi: 10.1038/mi.2016.72.
PMID:27579858

Related citations

graphicIgG Binding Characteristics of Rhesus Macaque FcγR.

Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles AR, Eckman JW, Alter G, Schmitz JE, Ackerman ME.
J Immunol. 2016 Aug 24. pii: 1502252.
PMID:27559046

Related citations

graphic Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.

Wright PF, Hoen AG, Ilyushina NA, Brown EP, Ackerman ME, Wieland-Alter W, Connor RI, Jegaskanda S, Rosenberg-Hasson Y, Haynes BC, Luke CJ, Subbarao K, Treanor JJ.
Open Forum Infect Dis. 2016 May 23;3(2):ofw108. doi: 10.1093/ofid/ofw108. eCollection 2016 Apr.
PMID:27419180

Related citations

graphic Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G.
Nat Med. 2016 May 30. doi: 10.1038/nm.4105. [Epub ahead of print]
PMID:27239761

Related citations

graphic Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G.
Mucosal Immunol. 2016 Feb 17. doi: 10.1038/mi.2016.12. [Epub ahead of print]
PMID:26883728

Related citations

graphic Engineering broadly neutralizing antibodies for HIV prevention and therapy.

Hua CK, Ackerman ME. Adv Drug Deliv Rev. 2016 Jan 28. pii: S0169-409X(16)30030-8. doi: 10.1016/j.addr.2016.01.013. [Epub ahead of print] Review.
PMID:26827912

Related citations

graphic Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.

Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G. PLoS Pathog. 2016 Jan 8;12(1):e1005315. doi: 10.1371/journal.ppat.1005315.
eCollection 2016 Jan.
PMID:26745376

Related citations

graphic Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G.
Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027.
PMID:26544943

Related citations

graphicThe role of Fc receptors in HIV prevention and therapy.

Boesch AW, Brown EP, Ackerman ME.
Immunol Rev. 2015 Nov;268(1):296-310. doi: 10.1111/imr.12339. Review.
PMID:26497529

Related citations

graphicEnhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.

Storcksdieck Genannt Bonsmann M, Niezold T, Temchura V, Pissani F, Ehrhardt K, Brown EP, Osei-Owusu NY, Hannaman D, Hengel H, Ackerman ME, Streeck H, Nabi G, Tenbusch M, Überla K.
J Immunol. 2015 Oct 14. pii: 1501377. [Epub ahead of print]
PMID:26466954

Related citations

graphicLambda light chain bias associated with enhanced binding and function of anti-HIV Env glycoprotein antibodies.

Sajadi MM, Farshidpour M, Brown EP, Ouyang X, Seaman MS, Pazgier M, Ackerman ME, Robinson H, Tomaras G, Parsons MS, Charurat M, DeVico AL, Redfield RR, Lewis GK.
J Infect Dis. 2015 Sep 7. pii: jiv448. [Epub ahead of print]
PMID:26347575

Related citations

graphicAntibody humanization by structure-based computational protein design.

Choi Y, Hua C, Sentman CL, Ackerman ME, Bailey-Kellogg C.
MAbs. 2015 Aug 7:0. [Epub ahead of print]
PMID:26252731

Related citations

graphicProtective efficacy of adenovirus-protein vaccines against SIV challenges in rhesus monkeys.

Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H..
Science. 2015 Jul 2. pii: aab3886.
PMID:26138104

Related citations

graphicMicroscale purification of antigen-specific antibodies.

Brown EP, Normandin E, Osei-Owusu NY, Mahan AE, Chan YN, Lai JI, Vaccari M, Rao M, Franchini G, Alter G, Ackerman ME.
J Immunol Methods. 2015 Jun 12. pii: S0022-1759(15)30007-7. doi: 10.1016/j.jim.2015.06.005. [Epub ahead of print]
PMID:26078040

Related citations

graphicMachine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees.

Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C.
PLoS Comput Biol. 2015 Apr 13;11(4):e1004185. doi: 10.1371/journal.pcbi.1004185. eCollection 2015 Apr.
PMID:25874406

Related citations

graphicDirected Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies.

Grimm SK, Battles MB, Ackerman ME.
PLoS One. 2015 Feb 17;10(2):e0117227. doi: 10.1371/journal.pone.0117227. eCollection 2015.
PMID: 25688555

Related citations

graphicProspects for engineering HIV-specific antibodies for enhanced effector function and half-life.

Boesch AW, Alter G, Ackerman ME.
Curr Opin HIV AIDS. 2015 Feb 19. [Epub ahead of print]
PMID: 25700208

graphicA method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis.

Mahan AE, Tedesco J, Dionne K, Baruah K, Cheng HD, De Jager PL, Barouch DH, Suscovich T, Ackerman M, Cripsin M, Alter G.
J Immunol Methods. 2014 Dec 15. pii: S0022-1759(14)00357-3. doi: 10.1016/j.jim.2014.12.004. [Epub ahead of print]
PMID: 25523925 [PubMed - as supplied by publisher]

graphicLive Attenuated and Inactivated Influenza Vaccines in Children.

Ilyushina NA, Haynes BC, Hoen AG, Khalenkov AM, Housman ML, Brown EP, Ackerman ME, Treanor JJ, Luke CJ, Subbarao K, Wright PF.
J Infect Dis. 2014 Aug 26. pii: jiu458. [Epub ahead of print]
PMID: 25165161 [PubMed - as supplied by publisher]

Related citations

graphicIdentification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function.

Chung AW, Crispin M, Pritchard L, Robinson H, Gorny MK, Yu X, Bailey-Kellogg C, Ackerman ME, Scanlan C, Zolla-Pazner S, Alter G.
AIDS. 2014 Aug 26. [Epub ahead of print]
PMID: 25160934 [PubMed - as supplied by publisher]

Related citations

graphicAn antibody tag-team: driving neutralization through escape.

Alter G, Ackerman ME.
Trends Immunol. 2014 Aug 14. pii: S1471-4906(14)00130-6. doi: 10.1016/j.it.2014.07.009. [Epub ahead of print]
PMID: 25131302 [PubMed - as supplied by publisher]

Related citations

graphicIndependent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection.

Dugast AS, Stamatatos L, Tonelli A, Suscovich TJ, Licht AF, Mikell I, Ackerman ME, Streeck H, Klasse PJ, Moore JP, Alter G. Eur J Immunol. 2014 Jul 10. doi: 10.1002/eji.201344305. [Epub ahead of print]
PMID: 25043633 [PubMed - as supplied by publisher]

Related citations

MAbsHighly parallel characterization of IgG Fc binding interactions.

Boesch AW, Brown EP, Cheng HD, Ofori MO, Normandin E, Nigrovic PA, Alter G, Ackerman ME.
MAbs. 2014 Jul 1;6(4):915-27. doi: 10.4161/mabs.28808
PMID: 24927273 [PubMed - in process]

Related citations

PLoS One 2014Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies.

Dugast AS, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G.
PLoS One. 2014 May 12;9(5):e97229. doi: 10.1371/journal.pone.0097229. eCollection 2014.
PMID: 24820481 [PubMed - in process]

Related citations

Sci Transl Med 2014Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines.

Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, Nitayaphan S, de Souza MS, Kaewkungwal J, Pitisuttithum P, Francis D, Michael NL, Kim JH, Bailey-Kellogg C, Ackerman ME, Alter G.
Sci Transl Med. 2014 Mar 19;6(228):228ra38. doi: 10.1126/scitranslmed.3007736.
PMID: 24648341 [PubMed - in process]

Related citations

J Clin Invest. 2014An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.
J Clin Invest. 2014 Mar 10. pii: 73441. doi: 10.1172/JCI73441.
[Epub ahead of print]
PMID: 24614107 [PubMed - as supplied by publisher]

Related citations

J Infect Dis 2014Intestinal Immunity Is a Determinant of Clearance of Poliovirus After Oral Vaccination.

Wright PF, Wieland-Alter W, Ilyushina NA, Hoen AG, Arita M, Boesch AW, Ackerman ME, van der Avoort H, Steven Oberste M, Pallansch MA, Burton AH, Jaffar MA, Sutter RW.
J Infect Dis. 2014 Jan 23. [Epub ahead of print]
PMID: 24459191 [PubMed - as supplied by publisher]

Related citations

J Virol 2013Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers.

Lai JI, Licht AF, Dugast AS, Suscovich T, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME.
J Virol. 2013 Dec 18. [Epub ahead of print]
PMID: 24352471 [PubMed - as supplied by publisher]

Related citations

Curr HIV Res.Opportunities to Exploit Non-Neutralizing HIV-Specific Antibody Activity

Ackerman ME, Alter G.
Curr HIV Res. 2013 Nov 4. [Epub ahead of print]
PMID: 24191934 [PubMed - as supplied by publisher]

Related citations

Academic PressAntibody Fc: Linking Adaptive and Innate Immunity

Margaret Ackerman, Falk Nimmerjahn (Editors)
Academic Press, Elsevier, 2013 Oct 4. ISBN-10: 0123948029 | ISBN-13: 978-0123948021

Journal Immunology MethodsA Multiplexed Assay to Detect Antimicrobial Peptides in Biological Fluids and Cell Secretions

Boesch AW, Zhao Y, Landman AS, Garcia MR, Fahey JV, Wira CR, Ackerman ME.
J Immunol Methods. 2013 Sep 10. doi:pii: S0022-1759(13)00241-X. 10.1016/j.jim.2013.09.001. [Epub ahead of print]

Related citations

New England Journal of MedicineMapping the journey to an HIV vaccine

Ackerman M, Alter G.
N Engl J Med. 2013 Jul 25;369(4):389-91. doi: 10.1056/NEJMcibr1304437. No abstract available.
PMID: 23883384 [PubMed - in process]

Related citations

J Clin InvestNatural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G.
J Clin Invest. 2013 Apr 8. doi:pii: 65708. 10.1172/JCI65708. [Epub ahead of print]
PMID: 23563315 [PubMed - as supplied by publisher]

Related citations

J Virol 2013Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b

Ackerman ME, Dugast AS, McAndrew EG, Tsoukas S, Licht AF, Irvine DJ, Alter G.
J Virol. 2013 Mar 6. [Epub ahead of print]
PMID: 23468489 [PubMed - as supplied by publisher]

Related citations

Curr Opin Biotechnol 2013Vaccine design: emerging concepts and renewed optimism

Grimm SK, Ackerman ME.
Curr Opin Biotechnol. 2013 Mar 6. doi:pii: S0958-1669(13)00029-3. 10.1016/j.copbio.2013.02.015. [Epub ahead of print]
PMID: 23474232 [PubMed - as supplied by publisher]

Related citations

Biotechnol Prog 2013Separation of nonfucosylated antibodies with immobilized FcγRIII receptors

Bolton GR, Ackerman ME, Boesch AW.
Biotechnol Prog. 2013 Mar 6. doi: 10.1021/btpr.1717. [Epub ahead of print]
PMID: 23463721 [PubMed - as supplied by publisher]

Related citations

J Immunol Methods. 2013 Jan 24What mAbs Tell Us about Shapes: Multiple Roads Lead to Rome

Alter G, Ackerman ME.
Immunity. 2013 Jan 24;38(1):8-9.
doi: 10.1016/j.immuni.2013.01.003. PMID: 23352219 [Epub ahead of print]

Related citations

J Immunol Methods. 2012 Sep 27High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

Brown EP, Licht AF, Dugast AS, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME.
J Immunol Methods. 2012 Sep 27.
pii: S0022-1759(12)00289-X. doi: 10.1016/j.jim.2012.09.007. [Epub ahead of print]

Annu Rev Med. 2012 FebEmerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection

Ackerman ME, Dugast AS, Alter G.
Annu Rev Med. 2012 Feb 18;63:113-30. Epub 2011 Nov 8.
PMID: 22077718 [PubMed - in process]

Related citations

J Vis Exp. 2011 NovDetermining the phagocytic activity of clinical antibody samples

McAndrew EG, Dugast AS, Licht AF, Eusebio JR, Alter G, Ackerman ME.
J Vis Exp. 2011 Nov 30;(57). pii: 3588. doi: 10.3791/3588.
PMID: 22143444 [PubMed - in process]

Related citations

Protein Eng Des Sel. 2011 NovExploiting bias in a non-immune human antibody library to predict antigenicity

Ackerman ME, Lai JI, Pastan I, Wittrup KD.
Protein Eng Des Sel. 2011 Nov;24(11):845-53. Epub 2011 Sep 9.
PMID: 21908549 [PubMed - in process]

Related citations

Virology. 2011 Jul 5

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals

Dugast AS, Tonelli A, Berger CT, Ackerman ME, Sciaranghella G, Liu Q, Sips M, Toth I, Piechocka-Trocha A, Ghebremichael M, Alter G.
Virology. 2011 Jul 5;415(2):160-7. Epub 2011 May 12.
PMID: 21565376 [PubMed - indexed for MEDLINE]

Related citations

PLoS One. 2011 AprProtein-protein fusion catalyzed by sortase A

Levary DA, Parthasarathy R, Boder ET, Ackerman ME.
PLoS One. 2011 Apr 6;6(4):e18342.
PMID: 21494692 [PubMed - indexed for MEDLINE] Free PMC Article

Related citations

J Immunol Methods. 2011 Mar A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

Ackerman ME, Moldt B, Wyatt RT, Dugast AS, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, Alter G.
J Immunol Methods. 2011 Mar 7;366(1-2):8-19. Epub 2010 Dec 27.
PMID: 21192942 [PubMed - indexed for MEDLINE]

Related citations

PLoS One. 2011 FebGenetically engineered alginate lyase-PEG conjugates exhibit enhanced catalytic function and reduced immunoreactivity

Lamppa JW, Ackerman ME, Lai JI, Scanlon TC, Griswold KE.
PLoS One. 2011 Feb 14;6(2):e17042.
PMID: 21340021 [PubMed - indexed for MEDLINE] Free PMC Article

Related citations

J Mol Biol. 2010 AugStability and CDR composition biases enrich binder functionality landscapes

Hackel BJ, Ackerman ME, Howland SW, Wittrup KD.
J Mol Biol. 2010 Aug 6;401(1):84-96. Epub 2010 Jun 9.
PMID: 20540948 [PubMed - indexed for MEDLINE]

Related citations

Protein Eng Des Sel 2010 AprA modular IgG-scFv bispecific antibody topology

Orcutt KD, Ackerman ME, Cieslewicz M, Quiroz E, Slusarczyk AL, Frangioni JV, Wittrup KD.
Protein Eng Des Sel. 2010 Apr;23(4):221-8. Epub 2009 Dec 17.
PMID: 20019028 [PubMed - indexed for MEDLINE] Free PMC Article

Related citations

Biotechnol Prog 2009Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display

Ackerman M, Levary D, Tobon G, Hackel B, Orcutt KD, Wittrup KD.
Biotechnol Prog. 2009 May-Jun;25(3):774-83.
PMID: 19363813 [PubMed - indexed for MEDLINE] Free PMC Article

Related citations

Mol Cancer Ther 2008Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

Ackerman ME, Pawlowski D, Wittrup KD.
Mol Cancer Ther. 2008 Jul;7(7):2233-40.
PMID: 18645032 [PubMed - indexed for MEDLINE] Free PMC Article

Related citations

Cancer Immunol Immunother 2008A33 antigen displays persistent surface expression

Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD.
Cancer Immunol Immunother. 2008 Jul;57(7):1017-27.
PMID: 18236042 [PubMed - indexed for MEDLINE] Free PMC Article