publications

28235027Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, Vasan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Liao HX, Ferrari G, Seaman MS, Montefiori DC, Tomaras GD, Harrison SC, Haynes BF.
PLoS Pathog. 2017 Feb 24;13(2):e1006182. doi: 10.1371/journal.ppat.1006182. [Epub ahead of print]
PMID:28235027

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28133810Systems serology for evaluation of HIV vaccine trials.

Ackerman ME, Barouch DH, Alter G.
Immunol Rev. 2017 Jan;275(1):262-270. doi: 10.1111/imr.12503. Review.
PMID:28133810

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28133810Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles.

Brown EP, Dowell KG, Boesch AW, Normandin E, Mahan AE, Chu T, Barouch DH, Bailey-Kellogg C, Alter G, Ackerman ME.
J Immunol Methods. 2017 Feb 2. pii: S0022-1759(16)30386-6. doi: 10.1016/j.jim.2017.01.010.
PMID:28163018

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graphicIgG Fc variant cross-reactivity between human and rhesus macaque FcγRs.

Boesch AW, Miles AR, Chan YN, Osei-Owusu NY, Ackerman ME.
MAbs. 2017 Jan 5:0. doi: 10.1080/19420862.2016.1274845.
PMID:28055295

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graphicBiophysical and Functional Characterization of Rhesus Macaque IgG Subclasses.

Boesch AW, Osei-Owusu NY, Crowley AR, Chu TH, Chan YN, Weiner JA, Bharadwaj P, Hards R, Adamo ME, Gerber SA, Cocklin SL, Schmitz JE, Miles AR, Eckman JW, Belli AJ, Reimann KA, Ackerman ME.
Front Immunol. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589.
PMID:28018355

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graphicDiversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects.

Huang Y, Ferrari G, Alter G, Forthal DN, Kappes JC, Lewis GK, Love JC, Borate B, Harris L, Greene K, Gao H, Phan TB, Landucci G, Goods BA, Dowell KG, Cheng HD, Bailey-Kellogg C, Montefiori DC, Ackerman ME.
J Immunol. 2016 Dec 15;197(12):4603-4612.
PMID:27913647

 

graphicVaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants.

Wright PF, Connor RI, Wieland-Alter WF, Hoen AG, Boesch AW, Ackerman ME, Oberste MS, Gast C, Brickley EB, Asturias EJ, Rüttimann R, Bandyopadhyay AS.
Lancet Infect Dis. 2016 Sep 13. pii: S1473-3099(16)30169-4. doi: 10.1016/S1473-3099(16)30169-4.
PMID:27638357

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graphicDendritic cells from the human female reproductive tract rapidly capture and respond to HIV.

Rodriguez-Garcia M, Shen Z, Barr FD, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C, Wira CR.
Mucosal Immunol. 2016 Aug 31. doi: 10.1038/mi.2016.72.
PMID:27579858

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graphicIgG Binding Characteristics of Rhesus Macaque FcγR.

Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles AR, Eckman JW, Alter G, Schmitz JE, Ackerman ME.
J Immunol. 2016 Aug 24. pii: 1502252.
PMID:27559046

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graphic Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.

Wright PF, Hoen AG, Ilyushina NA, Brown EP, Ackerman ME, Wieland-Alter W, Connor RI, Jegaskanda S, Rosenberg-Hasson Y, Haynes BC, Luke CJ, Subbarao K, Treanor JJ.
Open Forum Infect Dis. 2016 May 23;3(2):ofw108. doi: 10.1093/ofid/ofw108. eCollection 2016 Apr.
PMID:27419180

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graphic Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G.
Nat Med. 2016 May 30. doi: 10.1038/nm.4105. [Epub ahead of print]
PMID:27239761

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graphic Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G.
Mucosal Immunol. 2016 Feb 17. doi: 10.1038/mi.2016.12. [Epub ahead of print]
PMID:26883728

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graphic Engineering broadly neutralizing antibodies for HIV prevention and therapy.

Hua CK, Ackerman ME. Adv Drug Deliv Rev. 2016 Jan 28. pii: S0169-409X(16)30030-8. doi: 10.1016/j.addr.2016.01.013. [Epub ahead of print] Review.
PMID:26827912

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graphic Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.

Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G. PLoS Pathog. 2016 Jan 8;12(1):e1005315. doi: 10.1371/journal.ppat.1005315.
eCollection 2016 Jan.
PMID:26745376

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graphic Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G.
Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027.
PMID:26544943

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graphicThe role of Fc receptors in HIV prevention and therapy.

Boesch AW, Brown EP, Ackerman ME.
Immunol Rev. 2015 Nov;268(1):296-310. doi: 10.1111/imr.12339. Review.
PMID:26497529

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graphicEnhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells.

Storcksdieck Genannt Bonsmann M, Niezold T, Temchura V, Pissani F, Ehrhardt K, Brown EP, Osei-Owusu NY, Hannaman D, Hengel H, Ackerman ME, Streeck H, Nabi G, Tenbusch M, Überla K.
J Immunol. 2015 Oct 14. pii: 1501377. [Epub ahead of print]
PMID:26466954

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graphicLambda light chain bias associated with enhanced binding and function of anti-HIV Env glycoprotein antibodies.

Sajadi MM, Farshidpour M, Brown EP, Ouyang X, Seaman MS, Pazgier M, Ackerman ME, Robinson H, Tomaras G, Parsons MS, Charurat M, DeVico AL, Redfield RR, Lewis GK.
J Infect Dis. 2015 Sep 7. pii: jiv448. [Epub ahead of print]
PMID:26347575

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graphicAntibody humanization by structure-based computational protein design.

Choi Y, Hua C, Sentman CL, Ackerman ME, Bailey-Kellogg C.
MAbs. 2015 Aug 7:0. [Epub ahead of print]
PMID:26252731

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graphicProtective efficacy of adenovirus-protein vaccines against SIV challenges in rhesus monkeys.

Barouch DH, Alter G, Broge T, Linde C, Ackerman MEBrown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H..
Science. 2015 Jul 2. pii: aab3886.
PMID:26138104

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graphicMicroscale purification of antigen-specific antibodies.

Brown EP, Normandin E, Osei-Owusu NY, Mahan AE, Chan YN, Lai JI, Vaccari M, Rao M, Franchini G, Alter G, Ackerman ME.
J Immunol Methods. 2015 Jun 12. pii: S0022-1759(15)30007-7. doi: 10.1016/j.jim.2015.06.005. [Epub ahead of print]
PMID:26078040

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graphicMachine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees.

Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C.
PLoS Comput Biol. 2015 Apr 13;11(4):e1004185. doi: 10.1371/journal.pcbi.1004185. eCollection 2015 Apr.
PMID:25874406

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graphicDirected Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies.

Grimm SK, Battles MB, Ackerman ME.
PLoS One. 2015 Feb 17;10(2):e0117227. doi: 10.1371/journal.pone.0117227. eCollection 2015.
PMID: 25688555

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graphicProspects for engineering HIV-specific antibodies for enhanced effector function and half-life.

Boesch AW, Alter G, Ackerman ME.
Curr Opin HIV AIDS. 2015 Feb 19. [Epub ahead of print]
PMID: 25700208

graphicA method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis.

Mahan AE, Tedesco J, Dionne K, Baruah K, Cheng HD, De Jager PL, Barouch DH, Suscovich T, Ackerman M, Cripsin M, Alter G.
J Immunol Methods. 2014 Dec 15. pii: S0022-1759(14)00357-3. doi: 10.1016/j.jim.2014.12.004. [Epub ahead of print]
PMID: 25523925 [PubMed - as supplied by publisher]

graphicLive Attenuated and Inactivated Influenza Vaccines in Children.

Ilyushina NA, Haynes BC, Hoen AG, Khalenkov AM, Housman ML, Brown EP, Ackerman ME, Treanor JJ, Luke CJ, Subbarao K, Wright PF.
J Infect Dis. 2014 Aug 26. pii: jiu458. [Epub ahead of print]
PMID: 25165161 [PubMed - as supplied by publisher]

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graphicIdentification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function.

Chung AW, Crispin M, Pritchard L, Robinson H, Gorny MK, Yu X, Bailey-Kellogg C, Ackerman ME, Scanlan C, Zolla-Pazner S, Alter G.
AIDS. 2014 Aug 26. [Epub ahead of print]
PMID: 25160934 [PubMed - as supplied by publisher]

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graphicAn antibody tag-team: driving neutralization through escape.

Alter G, Ackerman ME.
Trends Immunol. 2014 Aug 14. pii: S1471-4906(14)00130-6. doi: 10.1016/j.it.2014.07.009. [Epub ahead of print]
PMID: 25131302 [PubMed - as supplied by publisher]

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graphicIndependent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection.

Dugast AS, Stamatatos L, Tonelli A, Suscovich TJ, Licht AF, Mikell I, Ackerman ME, Streeck H, Klasse PJ, Moore JP, Alter G. Eur J Immunol. 2014 Jul 10. doi: 10.1002/eji.201344305. [Epub ahead of print]
PMID: 25043633 [PubMed - as supplied by publisher]

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MAbsHighly parallel characterization of IgG Fc binding interactions.

Boesch AW, Brown EP, Cheng HD, Ofori MO, Normandin E, Nigrovic PA, Alter G, Ackerman ME.
MAbs. 2014 Jul 1;6(4):915-27. doi: 10.4161/mabs.28808
PMID: 24927273 [PubMed - in process]

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PLoS One 2014Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies.

Dugast AS, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G.
PLoS One. 2014 May 12;9(5):e97229. doi: 10.1371/journal.pone.0097229. eCollection 2014.
PMID: 24820481 [PubMed - in process]

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Sci Transl Med 2014Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines.

Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, Nitayaphan S, de Souza MS, Kaewkungwal J, Pitisuttithum P, Francis D, Michael NL, Kim JH, Bailey-Kellogg C, Ackerman ME, Alter G.
Sci Transl Med. 2014 Mar 19;6(228):228ra38. doi: 10.1126/scitranslmed.3007736.
PMID: 24648341 [PubMed - in process]

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J Clin Invest. 2014An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.
J Clin Invest. 2014 Mar 10. pii: 73441. doi: 10.1172/JCI73441.
[Epub ahead of print]
PMID: 24614107 [PubMed - as supplied by publisher]

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J Infect Dis 2014Intestinal Immunity Is a Determinant of Clearance of Poliovirus After Oral Vaccination.

Wright PF, Wieland-Alter W, Ilyushina NA, Hoen AG, Arita M, Boesch AW, Ackerman ME, van der Avoort H, Steven Oberste M, Pallansch MA, Burton AH, Jaffar MA, Sutter RW.
J Infect Dis. 2014 Jan 23. [Epub ahead of print]
PMID: 24459191 [PubMed - as supplied by publisher]

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J Virol 2013Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers.

Lai JI, Licht AF, Dugast AS, Suscovich T, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME.
J Virol. 2013 Dec 18. [Epub ahead of print]
PMID: 24352471 [PubMed - as supplied by publisher]

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Curr HIV Res.Opportunities to Exploit Non-Neutralizing HIV-Specific Antibody Activity

Ackerman ME, Alter G.
Curr HIV Res. 2013 Nov 4. [Epub ahead of print]
PMID: 24191934 [PubMed - as supplied by publisher]

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Academic PressAntibody Fc: Linking Adaptive and Innate Immunity

Margaret Ackerman, Falk Nimmerjahn (Editors)
Academic Press, Elsevier, 2013 Oct 4. ISBN-10: 0123948029 | ISBN-13: 978-0123948021

Journal Immunology MethodsA Multiplexed Assay to Detect Antimicrobial Peptides in Biological Fluids and Cell Secretions

Boesch AW, Zhao Y, Landman AS, Garcia MR, Fahey JV, Wira CR, Ackerman ME.
J Immunol Methods. 2013 Sep 10. doi:pii: S0022-1759(13)00241-X. 10.1016/j.jim.2013.09.001. [Epub ahead of print]

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New England Journal of MedicineMapping the journey to an HIV vaccine

Ackerman M, Alter G.
N Engl J Med. 2013 Jul 25;369(4):389-91. doi: 10.1056/NEJMcibr1304437. No abstract available.
PMID: 23883384 [PubMed - in process]

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J Clin InvestNatural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G.
J Clin Invest. 2013 Apr 8. doi:pii: 65708. 10.1172/JCI65708. [Epub ahead of print]
PMID: 23563315 [PubMed - as supplied by publisher]

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J Virol 2013Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b

Ackerman ME, Dugast AS, McAndrew EG, Tsoukas S, Licht AF, Irvine DJ, Alter G.
J Virol. 2013 Mar 6. [Epub ahead of print]
PMID: 23468489 [PubMed - as supplied by publisher]

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Curr Opin Biotechnol 2013Vaccine design: emerging concepts and renewed optimism

Grimm SK, Ackerman ME.
Curr Opin Biotechnol. 2013 Mar 6. doi:pii: S0958-1669(13)00029-3. 10.1016/j.copbio.2013.02.015. [Epub ahead of print]
PMID: 23474232 [PubMed - as supplied by publisher]

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Biotechnol Prog 2013Separation of nonfucosylated antibodies with immobilized FcγRIII receptors

Bolton GR, Ackerman ME, Boesch AW.
Biotechnol Prog. 2013 Mar 6. doi: 10.1021/btpr.1717. [Epub ahead of print]
PMID: 23463721 [PubMed - as supplied by publisher]

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J Immunol Methods. 2013 Jan 24What mAbs Tell Us about Shapes: Multiple Roads Lead to Rome

Alter G, Ackerman ME.
Immunity. 2013 Jan 24;38(1):8-9.
doi: 10.1016/j.immuni.2013.01.003. PMID: 23352219 [Epub ahead of print]

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J Immunol Methods. 2012 Sep 27High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

Brown EP, Licht AF, Dugast AS, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME.
J Immunol Methods. 2012 Sep 27.
pii: S0022-1759(12)00289-X. doi: 10.1016/j.jim.2012.09.007. [Epub ahead of print]

Annu Rev Med. 2012 FebEmerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection

Ackerman ME, Dugast AS, Alter G.
Annu Rev Med. 2012 Feb 18;63:113-30. Epub 2011 Nov 8.
PMID: 22077718 [PubMed - in process]

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J Vis Exp. 2011 NovDetermining the phagocytic activity of clinical antibody samples

McAndrew EG, Dugast AS, Licht AF, Eusebio JR, Alter G, Ackerman ME.
J Vis Exp. 2011 Nov 30;(57). pii: 3588. doi: 10.3791/3588.
PMID: 22143444 [PubMed - in process]

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Protein Eng Des Sel. 2011 NovExploiting bias in a non-immune human antibody library to predict antigenicity

Ackerman ME, Lai JI, Pastan I, Wittrup KD.
Protein Eng Des Sel. 2011 Nov;24(11):845-53. Epub 2011 Sep 9.
PMID: 21908549 [PubMed - in process]

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Virology. 2011 Jul 5

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals

Dugast AS, Tonelli A, Berger CT, Ackerman ME, Sciaranghella G, Liu Q, Sips M, Toth I, Piechocka-Trocha A, Ghebremichael M, Alter G.
Virology. 2011 Jul 5;415(2):160-7. Epub 2011 May 12.
PMID: 21565376 [PubMed - indexed for MEDLINE]

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PLoS One. 2011 AprProtein-protein fusion catalyzed by sortase A

Levary DA, Parthasarathy R, Boder ET, Ackerman ME.
PLoS One. 2011 Apr 6;6(4):e18342.
PMID: 21494692 [PubMed - indexed for MEDLINE] Free PMC Article

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J Immunol Methods. 2011 Mar A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

Ackerman ME, Moldt B, Wyatt RT, Dugast AS, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, Alter G.
J Immunol Methods. 2011 Mar 7;366(1-2):8-19. Epub 2010 Dec 27.
PMID: 21192942 [PubMed - indexed for MEDLINE]

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PLoS One. 2011 FebGenetically engineered alginate lyase-PEG conjugates exhibit enhanced catalytic function and reduced immunoreactivity

Lamppa JW, Ackerman ME, Lai JI, Scanlon TC, Griswold KE.
PLoS One. 2011 Feb 14;6(2):e17042.
PMID: 21340021 [PubMed - indexed for MEDLINE] Free PMC Article

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J Mol Biol. 2010 AugStability and CDR composition biases enrich binder functionality landscapes

Hackel BJ, Ackerman ME, Howland SW, Wittrup KD.
J Mol Biol. 2010 Aug 6;401(1):84-96. Epub 2010 Jun 9.
PMID: 20540948 [PubMed - indexed for MEDLINE]

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Protein Eng Des Sel 2010 AprA modular IgG-scFv bispecific antibody topology

Orcutt KD, Ackerman ME, Cieslewicz M, Quiroz E, Slusarczyk AL, Frangioni JV, Wittrup KD.
Protein Eng Des Sel. 2010 Apr;23(4):221-8. Epub 2009 Dec 17.
PMID: 20019028 [PubMed - indexed for MEDLINE] Free PMC Article

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Biotechnol Prog 2009Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display

Ackerman M, Levary D, Tobon G, Hackel B, Orcutt KD, Wittrup KD.
Biotechnol Prog. 2009 May-Jun;25(3):774-83.
PMID: 19363813 [PubMed - indexed for MEDLINE] Free PMC Article

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Mol Cancer Ther 2008Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

Ackerman ME, Pawlowski D, Wittrup KD.
Mol Cancer Ther. 2008 Jul;7(7):2233-40.
PMID: 18645032 [PubMed - indexed for MEDLINE] Free PMC Article

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Cancer Immunol Immunother 2008A33 antigen displays persistent surface expression

Ackerman ME, Chalouni C, Schmidt MM, Raman VV, Ritter G, Old LJ, Mellman I, Wittrup KD.
Cancer Immunol Immunother. 2008 Jul;57(7):1017-27.
PMID: 18236042 [PubMed - indexed for MEDLINE] Free PMC Article