Prodhi Manisha

Prodhi Manisha
Undergraduate Student

Thayer School of Engineering
Dartmouth College
14 Engineering Dr
Hanover, NH 03755

Lab: 603 646 6341



Engineering Sciences, Dartmouth College

Research Summary

I am working on developing and validating a novel yeast-based display system adapted for high-throughput fluorescence-activated sorting, which would allow for the expression of recombinant antigen proteins such as the HIV glycoproteins and receptors overexpressed in specific cancerous cells. Our end goal is to be able to utilize such a system for the characterization of the most effective antibodies and ligand proteins of therapeutic value against the expressed antigen, and to be able to do so in an accurate but efficient manner. I am particularly interested in recombinant protein engineering for treatment of diseases, particularly ones with heavy disease burdens in terms of mortality such as cancer and HIV. After a few feeble attempts at divesting myself of my proteomic prejudices, I have given up and admitted that antibodies are my favourite kind of protein out of them all, and I am planning my future pursuits to be in the field of immunoengineering.